Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer

BACKGROUND: Our previous studies have demonstrated that transduction of human dendritic cells (DC) with adenovirus encoding secondary lymphoid chemokine, CCL21, led to secretion of biologically active CCL21 without altering DC phenotype or viability. In addition, intratumoral injections of CCL21-tra...

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Main Authors: Baratelli, Felicita, Takedatsu, Hiroko, Hazra, Saswati, Peebles, Katherine, Luo, Jie, Kurimoto, Pam S, Zeng, Gang, Batra, Raj K, Sharma, Sherven, Dubinett, Steven M, Lee, Jay M
格式: Artigo
語言:Inglês
出版: BioMed Central 2008
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2507704/
https://ncbi.nlm.nih.gov/pubmed/18644162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-38
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