Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8(+) T Cells in HIV Infection

Recent studies have revealed the critical role of programmed death-1 (PD-1) in exhaustion of HIV- and SIV-specific CD8(+) T cells. In this study, we show that high expression of PD-1 correlates with increased ex vivo spontaneous and CD95/Fas-induced apoptosis, particularly in the “effector-memory” C...

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Hauptverfasser: Petrovas, Constantinos, Chaon, Benjamin, Ambrozak, David R., Price, David A., Melenhorst, J. Joseph, Hill, Brenna J., Geldmacher, Christof, Casazza, Joseph P., Chattopadhyay, Pratip K., Roederer, Mario, Douek, Daniel C., Mueller, Yvonne M., Jacobson, Jeffrey M., Kulkarni, Viraj, Felber, Barbara K., Pavlakis, George N., Katsikis, Peter D., Koup, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923541/
https://ncbi.nlm.nih.gov/pubmed/19564339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900182
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