Equal synthesis of α- and β-globin chains in erythroid precursors in heterozygous β-thalassemia
In patients with heterozygous β-thalassemia, the β/α synthetic ratio in marrow erythroid cells incubated in vitro is 1, whereas in reticulocytes the ratio is 0.5. These ratios reflect the equal synthesis of the two chains on the polyribosomes of the bone marrow and unequal synthesis on the polyribos...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
1972
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292339/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5032531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI106993 |
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