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Equal synthesis of α- and β-globin chains in erythroid precursors in heterozygous β-thalassemia

In patients with heterozygous β-thalassemia, the β/α synthetic ratio in marrow erythroid cells incubated in vitro is 1, whereas in reticulocytes the ratio is 0.5. These ratios reflect the equal synthesis of the two chains on the polyribosomes of the bone marrow and unequal synthesis on the polyribos...

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Detalhes bibliográficos
Main Authors: Kan, Yuet Wai, Nathan, David G., Lodish, Harvey F.
Formato: Artigo
Idioma:Inglês
Publicado em: 1972
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC292339/
https://ncbi.nlm.nih.gov/pubmed/5032531
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