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Herpes Simplex Virus Type 2 Glycoprotein E Is Required for Efficient Virus Spread from Epithelial Cells to Neurons and for Targeting Viral Proteins from the Neuron Cell Body into Axons
The HSV-2 lifecycle involves virus spread in a circuit from the inoculation site to dorsal root ganglia and return. We evaluated the role of gE-2 in the virus lifecycle by deleting amino acids 124–495 (gE2-del virus). In the mouse retina infection model, gE2-del virus does not spread to nuclei in th...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923263/ https://ncbi.nlm.nih.gov/pubmed/20598729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.06.006 |
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