Herpes Simplex Virus Type 2 Glycoprotein E Is Required for Efficient Virus Spread from Epithelial Cells to Neurons and for Targeting Viral Proteins from the Neuron Cell Body into Axons

The HSV-2 lifecycle involves virus spread in a circuit from the inoculation site to dorsal root ganglia and return. We evaluated the role of gE-2 in the virus lifecycle by deleting amino acids 124–495 (gE2-del virus). In the mouse retina infection model, gE2-del virus does not spread to nuclei in th...

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Hauptverfasser: Wang, Fushan, Zumbrun, Elizabeth E., Huang, Jialing, Si, Huaxin, Makaroun, Lena, Friedman, Harvey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923263/
https://ncbi.nlm.nih.gov/pubmed/20598729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.06.006
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