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Single-molecule FRET-derived model of the synaptotagmin 1–SNARE fusion complex
Synchronous neurotransmission is triggered when Ca(2+) binds to synaptotagmin 1, a synaptic vesicle protein that interacts with SNAREs and membranes. We used single-molecule FRET between synaptotagmin’s two C2 domains to determine that their conformation consists of multiple states with occasional t...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922927/ https://ncbi.nlm.nih.gov/pubmed/20173763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1763 |
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