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Single-molecule FRET-derived model of the synaptotagmin 1–SNARE fusion complex
Synchronous neurotransmission is triggered when Ca(2+) binds to synaptotagmin 1, a synaptic vesicle protein that interacts with SNAREs and membranes. We used single-molecule FRET between synaptotagmin’s two C2 domains to determine that their conformation consists of multiple states with occasional t...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922927/ https://ncbi.nlm.nih.gov/pubmed/20173763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1763 |
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