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Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases
dUTPases are essential for genome integrity. Recent results allowed characterization of the role of conserved residues. Here we analyzed the Asp/Asn mutation within conserved Motif I of human and mycobacterial dUTPases, wherein the Asp residue was previously implicated in Mg(2+)-coordination. Our re...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922844/ https://ncbi.nlm.nih.gov/pubmed/20493855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.05.018 |
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