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CaMKII control of spine size and synaptic strength: Role of phosphorylation states and nonenzymatic action

CaMKII is an abundant synaptic protein strongly implicated in plasticity. Overexpression of autonomous (T286D) CaMKII in CA1 hippocampal cells enhances synaptic strength if T305/T306 sites are not phosphorylated, but decreases synaptic strength if they are phosphorylated. It has generally been thoug...

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Autores principales: Pi, Hyun Jae, Otmakhov, Nikolai, El Gaamouch, Farida, Lemelin, David, De Koninck, Paul, Lisman, John
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922610/
https://ncbi.nlm.nih.gov/pubmed/20660727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009268107
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