Autonomous CaMKII Can Promote either Long-Term Potentiation or Long-Term Depression, Depending on the State of T305/T306 Phosphorylation

Ca(2+)/calmodulin-dependent kinase II (CaMKII) is a key mediator of long-term potentiation (LTP). Whereas acute intracellular injection of catalytically active CaMKII fragments saturates LTP (Lledo et al., 1995), an autonomously active form (T286D) of CaMKII holoenzyme expressed in transgenic mice d...

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Detalhes bibliográficos
Main Authors: Pi, Hyun Jae, Otmakhov, Nikolai, Lemelin, David, De Koninck, Paul, Lisman, John
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903435/
https://ncbi.nlm.nih.gov/pubmed/20592192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0133-10.2010
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