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CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy
Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving the chemokine receptor 4/stromal-derived cell factor 1 (CXCR4/SDF-1) axis are the major cause of ectopic overexpression of...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922579/ https://ncbi.nlm.nih.gov/pubmed/20660740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008256107 |
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