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Beneficial effects of antioxidants and l-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress

Atherogenesis is enhanced in arterial segments exposed to disturbed blood flow, indicating the active participation of the hemodynamic environment in lesion formation. Turbulent shear stress selectively regulates responsive genes in the endothelium and increases the damage induced by free radicals....

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Autors principals: de Nigris, Filomena, Lerman, Lilach O., Ignarro, Sharon Williams, Sica, Giacomo, Lerman, Amir, Palinski, Wulf, Ignarro, Louis J., Napoli, Claudio
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC298788/
https://ncbi.nlm.nih.gov/pubmed/12525696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237367100
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