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Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex

The tripartite protein exotoxin secreted by Bacillus anthracis, a major contributor to its virulence and anthrax pathogenesis, consists of binary complexes of the protective antigen (PA) heptamer (PA63h), produced by proteolytic cleavage of PA, together with either lethal factor or edema factor. The...

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Detalhes bibliográficos
Main Authors: Radjainia, Mazdak, Hyun, Jae-Kyung, Leysath, Clinton E., Leppla, Stephen H., Mitra, Alok K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922573/
https://ncbi.nlm.nih.gov/pubmed/20660775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006473107
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