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Model of the toxic complex of anthrax: Responsive conformational changes in both the lethal factor and the protective antigen heptamer
The toxic complex of anthrax is formed when the monomeric protective antigen (PA) (83 kDa), while bound to its cell-surface receptor, is first converted to PA63 heptamers (PA63h) following N-terminal proteolytic cleavage, and then lethal (LF) (90 kDa) or edema factor (EF) binds to the heptamer. We r...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242606/ https://ncbi.nlm.nih.gov/pubmed/16943448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062293906 |
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