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Promotion of direct reprogramming by transformation-deficient Myc

Induced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene product c-Myc markedly promotes iPSC generation, but also increases tumor formation in iPSC-derived chimeric mice. We r...

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Detalhes bibliográficos
Main Authors: Nakagawa, Masato, Takizawa, Nanako, Narita, Megumi, Ichisaka, Tomoko, Yamanaka, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922531/
https://ncbi.nlm.nih.gov/pubmed/20660764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009374107
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