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An Ethnic-Specific Polymorphism in the Catalytic Subunit of Glutamate-Cysteine Ligase Impairs the Production of Glutathione Intermediates In Vitro
Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of glutamate cysteine ligase (GCLC), the rate-limiting enzyme in glutathione biosynthesi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922432/ https://ncbi.nlm.nih.gov/pubmed/20655259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2010.05.013 |
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