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Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

A common strategy of metabolic engineering is to increase the endogenous supply of precursor metabolites to improve pathway productivity. The ability to further enhance heterologous production of a desired compound may be limited by the inherent capacity of the imported pathway to accommodate high p...

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Main Authors: Leonard, Effendi, Ajikumar, Parayil Kumaran, Thayer, Kelly, Xiao, Wen-Hai, Mo, Jeffrey D., Tidor, Bruce, Stephanopoulos, Gregory, Prather, Kristala L. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922259/
https://ncbi.nlm.nih.gov/pubmed/20643967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006138107
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