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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). W...

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Päätekijät: Saxena, Richa, Hivert, Marie-France, Langenberg, Claudia, Tanaka, Toshiko, Pankow, James S, Vollenweider, Peter, Lyssenko, Valeriya, Bouatia-Naji, Nabila, Dupuis, Josée, Jackson, Anne U, Kao, W H Linda, Li, Man, Glazer, Nicole L, Manning, Alisa K, Luan, Jian’an, Stringham, Heather M, Prokopenko, Inga, Johnson, Toby, Grarup, Niels, Boesgaard, Trine W, Lecoeur, Cécile, Shrader, Peter, O’Connell, Jeffrey, Ingelsson, Erik, Couper, David J, Rice, Kenneth, Song, Kijoung, Andreasen, Camilla H, Dina, Christian, Köttgen, Anna, Le Bacquer, Olivier, Pattou, François, Taneera, Jalal, Steinthorsdottir, Valgerdur, Rybin, Denis, Ardlie, Kristin, Sampson, Michael, Qi, Lu, van Hoek, Mandy, Weedon, Michael N, Aulchenko, Yurii S, Voight, Benjamin F, Grallert, Harald, Balkau, Beverley, Bergman, Richard N, Bielinski, Suzette J, Bonnefond, Amelie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Buchanan, Thomas A, Bumpstead, Suzannah J, Cavalcanti-Proença, Christine, Charpentier, Guillaume, Chen, Yii-Der Ida, Chines, Peter S, Collins, Francis S, Cornelis, Marilyn, Crawford, Gabriel J, Delplanque, Jerome, Doney, Alex, Egan, Josephine M, Erdos, Michael R, Firmann, Mathieu, Forouhi, Nita G, Fox, Caroline S, Goodarzi, Mark O, Graessler, Jürgen, Hingorani, Aroon, Isomaa, Bo, Jørgensen, Torben, Kivimaki, Mika, Kovacs, Peter, Krohn, Knut, Kumari, Meena, Lauritzen, Torsten, Lévy-Marchal, Claire, Mayor, Vladimir, McAteer, Jarred B, Meyre, David, Mitchell, Braxton D, Mohlke, Karen L, Morken, Mario A, Narisu, Narisu, Palmer, Colin N A, Pakyz, Ruth, Pascoe, Laura, Payne, Felicity, Pearson, Daniel, Rathmann, Wolfgang, Sandbaek, Annelli, Sayer, Avan Aihie, Scott, Laura J, Sharp, Stephen J, Sijbrands, Eric, Singleton, Andrew, Siscovick, David S, Smith, Nicholas L, Sparsø, Thomas, Swift, Amy J, Syddall, Holly, Thorleifsson, Gudmar, Tönjes, Anke, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Waeber, Gérard, Walley, Andrew, Waterworth, Dawn M, Zeggini, Eleftheria, Zhao, Jing Hua, Illig, Thomas, Wichmann, H Erich, Wilson, James F, van Duijn, Cornelia, Hu, Frank B, Morris, Andrew D, Frayling, Timothy M, Hattersley, Andrew T, Thorsteinsdottir, Unnur, Stefansson, Kari, Nilsson, Peter, Syvänen, Ann-Christine, Shuldiner, Alan R, Walker, Mark, Bornstein, Stefan R, Schwarz, Peter, Williams, Gordon H, Nathan, David M, Kuusisto, Johanna, Laakso, Markku, Cooper, Cyrus, Marmot, Michael, Ferrucci, Luigi, Mooser, Vincent, Stumvoll, Michael, Loos, Ruth J F, Altshuler, David, Psaty, Bruce M, Rotter, Jerome I, Boerwinkle, Eric, Hansen, Torben, Pedersen, Oluf, Florez, Jose C, McCarthy, Mark I, Boehnke, Michael, Barroso, Inês, Sladek, Robert, Froguel, Philippe, Meigs, James B, Groop, Leif, Wareham, Nicholas J, Watanabe, Richard M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922003/
https://ncbi.nlm.nih.gov/pubmed/20081857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.521
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