Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase

BACKGROUND: Failure of antiretroviral therapy may result from the selection of pre-existing, drug-resistant HIV-1 variants, but the frequency and type of such variants have not been defined. OBJECTIVE: We used single genome sequencing (SGS) to characterize the frequency of polymorphism at drug resis...

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Main Authors: Kearney, Mary, Palmer, Sarah, Maldarelli, Frank, Shao, Wei, Polis, Michael A., Mican, JoAnn, Rock-Kress, Diane, Margolick, Joseph B., Coffin, John M., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921824/
https://ncbi.nlm.nih.gov/pubmed/18301062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3282f29478
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