Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

Axons of adult Caenorhabditis elegans neurons undergo robust regenerative growth after laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium waves whose amplitude correlates with the extent of regeneration. Genetic elevation of Ca(2+) or cAMP accelerates formation o...

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Bibliographic Details
Main Authors: Ghosh-Roy, Anindya, Wu, Zilu, Goncharov, Alexandr, Jin, Yishi, Chisholm, Andrew D.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921707/
https://ncbi.nlm.nih.gov/pubmed/20203177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5464-09.2010
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