Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats

RATIONALE: Chronic opiate administration induces neuro-adaptations within the nucleus accumbens (NAc) and ventral tegmental area (VTA) that can contribute to dependence. We have shown that morphine dependence shifts the behavioral consequences of D1 dopamine (DA) receptor signaling: systemic adminis...

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Main Authors: Chartoff, Elena H., Barhight, Matthew F., Mague, Steve D., Sawyer, Allison M., Carlezon, William A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921644/
https://ncbi.nlm.nih.gov/pubmed/19148621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-008-1454-7
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