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Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum

Chronic morphine leads to compensatory up-regulation of cAMP signaling pathways in numerous brain regions. One potential consequence of up-regulated cAMP signaling is increased phosphorylation of cAMP response element binding protein (CREB), a transcription factor that may regulate neuroadaptations...

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Main Authors: Chartoff, Elena H., Papadopoulou, Maria, Konradi, Christine, Carlezon, William A.
格式: Artigo
語言:Inglês
出版: 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205588/
https://ncbi.nlm.nih.gov/pubmed/12969258
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