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Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis

PHLPP (PH domain Leucine-rich-repeats Protein Phosphatase) represents a family of novel Ser/Thr protein phosphatases. Two highly related isoforms in this family, PHLPP1 and PHLPP2, have been identified to serve as negative regulators of Akt and protein kinase C (PKC) by dephosphorylating the kinases...

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Detalles Bibliográficos
Main Authors: Liu, Jianyu, Weiss, Heidi L., Rychahou, Piotr, Jackson, Lindsey N., Evers, B. Mark, Gao, Tianyan
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921630/
https://ncbi.nlm.nih.gov/pubmed/19079341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.450
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