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Kinetic Mechanistic Studies of Cdk5/p25-Catalyzed H1P Phosphorylation: Metal Effect and Solvent Kinetic Isotope Effect
Cdk5/p25 is a member of the cyclin-dependent, Ser/Thr kinase family and has been identified as one of the principle Alzheimer’s disease-associated kinases which promote the formation of hyperphoshorylated tau, the major component of neurofibrillary tangles. We and others have been developing inhibit...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921628/ https://ncbi.nlm.nih.gov/pubmed/20491486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100244j |
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