Metformin Selectively Attenuates Mitochondrial H(2)O(2) Emission without Affecting Respiratory Capacity in Skeletal Muscle of Obese Rats

Metformin is a widely prescribed drug for treatment of type 2 diabetes, although no cellular mechanism of action has been established. To determine whether in vivo metformin treatment alters mitochondrial function in skeletal muscle, respiratory O(2) flux and H(2)O(2) emission were measured in sapon...

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Detalhes bibliográficos
Main Authors: Kane, Daniel A., Anderson, Ethan J., Price, Jesse W., Woodlief, Tracey L., Lin, Chien-Te, Bikman, Benjamin T., Cortright, Ronald N., Neufer, P. Darrell
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921476/
https://ncbi.nlm.nih.gov/pubmed/20600832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.06.022
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