Mitochondrial H(2)O(2) emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been implicated in the disease process, but the underlying mechanisms are still unknown....

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Autors principals: Anderson, Ethan J., Lustig, Mary E., Boyle, Kristen E., Woodlief, Tracey L., Kane, Daniel A., Lin, Chien-Te, Price, Jesse W., Kang, Li, Rabinovitch, Peter S., Szeto, Hazel H., Houmard, Joseph A., Cortright, Ronald N., Wasserman, David H., Neufer, P. Darrell
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648700/
https://ncbi.nlm.nih.gov/pubmed/19188683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37048
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