Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKβ Action in a Fiber-Type Specific Manner

Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) in this same tissue are unknown. The aim of this study was to (1) determine th...

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Detalhes bibliográficos
Main Authors: Bikman, Benjamin T., Zheng, Donghai, Kane, Daniel A., Anderson, Ethan J., Woodlief, Tracey L., Price, Jesse W., Dohm, G. Lynis, Neufer, P. Darrell, Cortright, Ronald N.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925476/
https://ncbi.nlm.nih.gov/pubmed/20798864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/970865
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