AAVrh.10-mediated Genetic Delivery of Bevacizumab to the Pleura to Provide Local Anti-VEGF to Suppress Growth of Metastatic Lung Tumors

Vascular endothelial growth factor (VEGF) produced by tumor cells plays a central role in stimulating angiogenesis required for tumor growth. Humanized monoclonal anti-VEGF antibody (bevacizumab, Avastin(®)), approved as a treatment for non-squamous, non-small cell lung cancer, requires administrati...

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Hlavní autoři: Watanabe, Masaki, Boyer, Julie L., Crystal, Ronald G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921016/
https://ncbi.nlm.nih.gov/pubmed/20596059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.87
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