Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

Developmental abnormalities, cancer and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pre-gastrulation lethality) and humans (Seckel syndrome). Herein we show that eliminating ATR in a...

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Bibliografiske detaljer
Main Authors: Ruzankina, Yaroslava, Pinzon-Guzman, Carolina, Asare, Amma, Ong, Tony, Pontano, Laura, Cotsarelis, George, Zediak, Valerie P., Velez, Marielena, Bhandoola, Avinash, Brown, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920603/
https://ncbi.nlm.nih.gov/pubmed/18371340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2007.03.002
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