Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR ortholog (MEI-41) is essential for preventing entry in...

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Main Authors: LaRocque, Jeannine R., Dougherty, Diana L., Hussain, Sumreen K., Sekelsky, Jeff
Formato: Artigo
Idioma:Inglês
Publicado: Copyright © 2007 by the Genetics Society of America 2007
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Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1931523/
https://ncbi.nlm.nih.gov/pubmed/17483406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.073635
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