Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR ortholog (MEI-41) is essential for preventing entry in...

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Hlavní autoři: LaRocque, Jeannine R., Dougherty, Diana L., Hussain, Sumreen K., Sekelsky, Jeff
Médium: Artigo
Jazyk:Inglês
Vydáno: Copyright © 2007 by the Genetics Society of America 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1931523/
https://ncbi.nlm.nih.gov/pubmed/17483406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.073635
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