Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR ortholog (MEI-41) is essential for preventing entry in...

Full description

Saved in:
Bibliographic Details
Main Authors: LaRocque, Jeannine R., Dougherty, Diana L., Hussain, Sumreen K., Sekelsky, Jeff
Format: Artigo
Language:Inglês
Published: Copyright © 2007 by the Genetics Society of America 2007
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1931523/
https://ncbi.nlm.nih.gov/pubmed/17483406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.073635
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items