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Activation of Rac1 promotes Hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells
Hepatic accumulation of myofibroblastic hepatic stellate cells (MF-HSC) is pivotal in the pathogenesis of cirrhosis. Two events are necessary for MF-HSC to accumulate in damaged livers: transition of resident, quiescent HSC (Q-HSC) to MF-HSC, and expansion of MF-HSC numbers via increased proliferati...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920128/ https://ncbi.nlm.nih.gov/pubmed/20578145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23649 |
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