Activation of Rac1 promotes Hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells

Hepatic accumulation of myofibroblastic hepatic stellate cells (MF-HSC) is pivotal in the pathogenesis of cirrhosis. Two events are necessary for MF-HSC to accumulate in damaged livers: transition of resident, quiescent HSC (Q-HSC) to MF-HSC, and expansion of MF-HSC numbers via increased proliferati...

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Autores principales: Choi, Steve S., Witek, Rafal P., Yang, Liu, Omenetti, Alessia, Syn, Wing-Kin, Moylan, Cynthia A., Jung, Youngmi, Karaca, Gamze F., Teaberry, Vanessa S., Pereira, Thiago A., Wang, Jiangbo, Ren, Xiu-Rong, Diehl, Anna Mae
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920128/
https://ncbi.nlm.nih.gov/pubmed/20578145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23649
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