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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920127/ https://ncbi.nlm.nih.gov/pubmed/20098421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1768 |
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