Identification of thymidylate synthase as a potential therapeutic target for lung cancer

BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Although inhibition of TS has an antiproliferative effect in cancer cells, the precise mechanism of this effect has remained...

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Main Authors: Takezawa, K, Okamoto, I, Tsukioka, S, Uchida, J, Kiniwa, M, Fukuoka, M, Nakagawa, K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920030/
https://ncbi.nlm.nih.gov/pubmed/20628382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605793
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