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Identification of thymidylate synthase as a potential therapeutic target for lung cancer
BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Although inhibition of TS has an antiproliferative effect in cancer cells, the precise mechanism of this effect has remained...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920030/ https://ncbi.nlm.nih.gov/pubmed/20628382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605793 |
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