Identification of thymidylate synthase as a potential therapeutic target for lung cancer

BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Although inhibition of TS has an antiproliferative effect in cancer cells, the precise mechanism of this effect has remained...

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Bibliografiska uppgifter
Huvudupphovsmän: Takezawa, K, Okamoto, I, Tsukioka, S, Uchida, J, Kiniwa, M, Fukuoka, M, Nakagawa, K
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2010
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920030/
https://ncbi.nlm.nih.gov/pubmed/20628382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605793
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