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Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans
Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that become more insoluble with age in the multicellular org...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919420/ https://ncbi.nlm.nih.gov/pubmed/20711477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000450 |
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