Siah2-dependent concerted activity of HIF & FoxA2 regulates formation of neuroendocrine phenotype & neuroendocrine prostate tumors

Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1α availabili...

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Main Authors: Qi, Jianfei, Nakayama, Koh, Cardiff, Robert D., Borowsky, Alexander D., Kaul, Karen, Williams, Roy, Krajewski, Stan, Mercola, Dan, Carpenter, Philip M., Bowtell, David, Ronai, Ze’ev A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919332/
https://ncbi.nlm.nih.gov/pubmed/20609350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.05.024
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