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Up-regulation of the ATPase Inhibitory Factor 1 (IF1) of the Mitochondrial H(+)-ATP Synthase in Human Tumors Mediates the Metabolic Shift of Cancer Cells to a Warburg Phenotype

The H(+)-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and progression of diverse human pathologies. During ischemia, the ATP hydrolytic activity of the enzyme is inhibited by...

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書誌詳細
主要な著者: Sánchez-Cenizo, Laura, Formentini, Laura, Aldea, Marcos, Ortega, Álvaro D., García-Huerta, Paula, Sánchez-Aragó, María, Cuezva, José M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919093/
https://ncbi.nlm.nih.gov/pubmed/20538613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146480
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