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Human Base Excision Repair Creates a Bias Toward −1 Frameshift Mutations
Frameshift mutations are particularly deleterious to protein function and play a prominent role in carcinogenesis. Most commonly these mutations involve the insertion or omission of a single nucleotide by a DNA polymerase that slips on a damaged or undamaged template. The mismatch DNA repair pathway...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919083/ https://ncbi.nlm.nih.gov/pubmed/20547483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118596 |
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