Factor VIII Lacking the C2 Domain Retains Cofactor Activity in Vitro

Factor (F) VIII consists of a heavy chain (A1A2B domains) and light chain (A3C1C2 domains). The activated form of FVIII, FVIIIa, functions as a cofactor for FIXa in catalyzing the membrane-dependent activation of FX. Whereas the FVIII C2 domain is believed to anchor FVIIIa to the phospholipid surfac...

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Bibliographische Detailangaben
Hauptverfasser: Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919080/
https://ncbi.nlm.nih.gov/pubmed/20529839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106906
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