Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members

The four WNK (with no lysine (K)) protein kinases affect ion balance and contain an unusual protein kinase domain due to the unique placement of the active site lysine. Mutations in two WNKs cause a heritable form of ion imbalance culminating in hypertension. WNK1 activates the serum- and glucocorti...

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Autors principals: Heise, Charles J., Xu, Bing-e, Deaton, Staci L., Cha, Seung-Kuy, Cheng, Chih-Jen, Earnest, Svetlana, Sengupta, Samarpita, Juang, Yu-Chi, Stippec, Steve, Xu, Yingda, Zhao, Yingming, Huang, Chou-Long, Cobb, Melanie H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919078/
https://ncbi.nlm.nih.gov/pubmed/20525693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103432
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