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Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents
Our triazole-based histone deacetylase inhibitor (HDACI), octanedioic acid hydroxyamide[3-(1-phenyl-1H-[1,2,3]triazol-4-yl)phenyl]amide (4a), suppresses pancreatic cancer cell growth in vitro, with the lowest IC(50) value of 20 nM against MiaPaca-2 cell. In this study, we continued our efforts to de...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919064/ https://ncbi.nlm.nih.gov/pubmed/20055418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901667k |
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