Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors

The antimalarial activity and pharmacology of a series of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors (HDACIs) was evaluated. In in vitro growth inhibition assays approximately 50 analogs were evaluated against four drug resistant strains of Plasmodium falciparum. The ra...

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Detalhes bibliográficos
Main Authors: Dow, Geoffrey S., Chen, Yufeng, Andrews, Katherine T., Caridha, Diana, Gerena, Lucia, Gettayacamin, Montip, Johnson, Jacob, Li, Qigui, Melendez, Victor, Obaldia, Nicanor, Tran, Thanh N., Kozikowski, Alan P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565884/
https://ncbi.nlm.nih.gov/pubmed/18644969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00439-08
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