Molecular Basis of Neurovirulence of Flury Rabies Virus Vaccine Strains: Importance of the Polymerase and the Glycoprotein R333Q Mutation

The molecular mechanisms associated with rabies virus (RV) virulence are not fully understood. In this study, the RV Flury low-egg-passage (LEP) and high-egg-passage (HEP) strains were used as models to explore the attenuation mechanism of RV. The results of our studies confirmed that the R333Q muta...

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Bibliographic Details
Main Authors: Tao, Lihong, Ge, Jinying, Wang, Xijun, Zhai, Hongyue, Hua, Tao, Zhao, Bolin, Kong, Dongni, Yang, Chinglai, Chen, Hualan, Bu, Zhigao
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919041/
https://ncbi.nlm.nih.gov/pubmed/20538851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00787-10
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