Poly(A)-Binding Protein 1 Partially Relocalizes to the Nucleus during Herpes Simplex Virus Type 1 Infection in an ICP27-Independent Manner and Does Not Inhibit Virus Replication

Infection of cells by herpes simplex virus type 1 (HSV-1) triggers host cell shutoff whereby mRNAs are degraded and cellular protein synthesis is diminished. However, virus protein translation continues because the translational apparatus in HSV-infected cells is maintained in an active state. Surpr...

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Main Authors: Salaun, C., MacDonald, A. I., Larralde, O., Howard, L., Lochtie, K., Burgess, H. M., Brook, M., Malik, P., Gray, N. K., Graham, S. V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919032/
https://ncbi.nlm.nih.gov/pubmed/20573819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00668-10
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