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Activation of the Interferon Response by Human Cytomegalovirus Occurs via Cytoplasmic Double-Stranded DNA but Not Glycoprotein B

In vitro infection of cells with the betaherpesvirus human cytomegalovirus (HCMV) stimulates an innate immune response characterized by phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent expression of IRF3-dependent genes. While previous work suggests th...

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Bibliografiske detaljer
Main Authors: DeFilippis, Victor R., Sali, Tina, Alvarado, David, White, Laura, Bresnahan, Wade, Früh, Klaus J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919031/
https://ncbi.nlm.nih.gov/pubmed/20573816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00169-10
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