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Method for Designing and Optimizing Random-Search Libraries for Strain Improvement
Random searches have been the hallmark of directed evolution and have been extensively employed in the improvement of complex or poorly understood phenotypes such as tolerance to toxic compounds in the context of cellular engineering. While genome-wide mutagenesis followed by selection or screening...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918980/ https://ncbi.nlm.nih.gov/pubmed/20581192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00828-10 |
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